Pharmacological Effects of Antiarrhythmic Drugs

Pharmacological effects of antiarrhythmic drugs. Review and update.

Most antiarrhythmic drugs are potent compounds with a relatively narrow therapeutic index. When prescribed judiciously, they can have a key role in enhancing or prolonging the lives of patients with most common arrhythmias. But when misprescribed, through selection of an inappropriate drug or dosage regimen, the end result may range from inadequate control of the arrhythmia to a proarrhythmic e...

Antiarrhythmic drugs.

Most patients with cardiac arrhythmias require treatment with antiarrhythmic drugs, although recent advances in surgical and electrical techniques are promising. The ideal antiarrhythmic compound should have: (1) A wide range of therapeutic activity in both atrial and ventricular arrhythmias. (2) Parenteral and oral formulations to permit simple dosage schedules. (3) Pharmacokinetic properties ...

Antiarrhythmic Drugs

Cardiac arrhythmias result from alterations in the orderly sequence of depolarization followed by repolarization in the heart. Cardiac arrhythmias may result in alterations in heart rate or rhythm and arise from alterations in impulse generation or conduction. The clinical implications of disordered cardiac activation range from asymptomatic palpitations to lethal arrhythmia. Pharmacological ma...

Adverse hemodynamic effects of antiarrhythmic drugs in congestive heart failure.

Influence of the absolute configuration on pharmacological activity of antihypertensive and antiarrhythmic drugs.

Chirality is a fundamental property of biological systems and reflects the underlying asymmetry of matter. Interactions of drugs with receptors, enzymes or binding sites have long been known to be stereoselective, and it is increasingly recognized that both pharmacodynamic and pharmacokinetic events contribute to the overall clinically observed stereoselectivity. The pharmacological activity ma...